Disease definition. Fetal hydantoin syndrome is a drug-related embryofetopathy that can occur when an embryo/fetus is exposed to the anticonvulsant drug. A clinical diagnosis of fetal hydantoin syndrome secondary to in utero phenytoin exposure was considered. Investigations showed vitamin D. This page includes the following topics and synonyms: Fetal Hydantoin Syndrome.

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For information about clinical trials sponsored by private sources, contact: Related Topics in Pharmacology. The content of the website and databases of the National Organization for Rare Disorders NORD is copyrighted and may not be reproduced, copied, downloaded or disseminated, in any way, for any commercial or public purpose, without prior written authorization and approval from NORD.

Infants with fetal hydantoin syndrome can benefit from early developmental intervention to ensure that affected children reach their potential.

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Association with EPHX1 has been suggested. There is no diagnostic testing that can identify fetal hydantoin syndrome. Years Published, Fetal hydantoin syndrome may be caused by a combination of specific genetic and environmental factors. Am J Med Genet A.

Retrieved from ” https: The fetal hydantoin syndrome. World Health Organization; Congenital malformation due to exogenous toxicity Syndromes. Surgical repair can be carried out in stages or in a single operation, according to the nature and severity of the defect.

From Wikipedia, the free encyclopedia. Foetal antiepileptic drug exposure and verbal versus non-verbal abilities at three years of age. Also, it is recommended that women taking phenytoin take folic acid supplements, both before conception and during pregnancy as a preventive measure against malformations.


Front profi le Click here to view. Reports in the medical literature disagree as to the likelihood of infants with fetal hydantoin syndrome experiencing developmental delays or intellectual disability.

High arch palate Click here to view. Treatment The treatment of fetal hydantoin syndrome is directed toward the specific symptoms that are apparent in each individual. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years NEAD study: General Discussion Summary Fetal hydantoin syndrome is a characteristic pattern of mental and physical birth defects that results from maternal use of the anti-seizure anticonvulsant drug phenytoin Dilantin during pregnancy.

Investigational Therapies Information on current clinical trials is posted on the Internet at www.

Fetal Hydantoin Syndrome – NORD (National Organization for Rare Disorders)

Treatment may require the coordinated efforts of a team of specialists. Related Bing Images Extra: Feeding difficulties and frequent respiratory infections during infancy, diminished muscle tone hypotoniaabnormal looseness laxity of the joints, delayed bone age, developmental delays, hearing loss, and intellectual disability may also be present.

Related Disorders Symptoms of the following disorders can be similar to those of fetal hydantoin syndrome. Borderline to mild intellectual disability has been reported in some cases, and some studies have suggested that children exposed to phenytoin in the womb have a feta risk of developing learning disabilities, particularly in verbal skills.

Back Links pages that link to this page. The epidemiology of epilepsy in Rochester, Minnesota, through Radiograph of 85 Click here to view. Several factors including the small number of identified cases, the lack of large clinical studies, and the possibility of genes or other factors influencing the disorder prevent physicians from developing an accurate picture of associated symptoms and prognosis.

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Therefore, it is important to note that affected individuals may not have all of the symptoms discussed below. Heart defects and cleft lip [3] may also be featured. Flat nasal bridge, ptosis of right upper eyelid, strabismus, and watery eyes Click here to view. Fetal hydantoin syndrome C Case Rep Anesthesiol ; Fetal alcohol syndrome FAS is a characteristic pattern of mental and physical birth defects that results due to maternal use of alcohol during pregnancy.

The specific amount of phenytoin ingestion required to cause the disorder has not been determined. Affected children may benefit from occupational, physical and speech therapy.

Differential Diagnosis Fetal Alcohol Syndrome. Right side in occlusion Click here to view. The neurological effects of phenytoin exposure in utero have not been clearly established hydajtoin studies, which have demonstrated conflicting results.

Obstetrics – Pharmacology Pages.

Definition NCI A teratogenic disorder observed in a newborn or child of a mother who was exposed to phenytoin during pregnancy. Only comments seeking to improve the quality and accuracy of information on the Orphanet website are accepted. Prevention It is recommended that women be treated with hydxntoin single anticonvulsant prior to conception and throughout pregnancy, since it appears that children syndorme to multiple anticonvulsants may be at a greater risk for significant birth defects.

Buehler BA, Finnell R.